Dartmouth researchers were awarded $ 29.9 million during June, including $20.7 million in new and competing awards. View the , as reported by the . Here, Dartmouth Now spotlights three investigators and their work.
, associate professor of biologyNational Institute of General Medical Sciences 鈥淩egulation of Sister-Chromatid Cohesion in Drosophila Meiosis鈥
Chromosome choreography: When a cell divides, it is critical that each of the daughter cells inherits a complete set of chromosomes. 鈥淓rrors in chromosome segregation can be catastrophic, especially in meiosis, the specialized type of cell division that gives rise to sperm and eggs,鈥 Bickel says. 鈥淭his award focuses on understanding how chromosomes 鈥榙o the right thing鈥 during meiosis.鈥
Sticky sisters: One essential component of accurate cell division is the glue (cohesion) that holds sister chromatids together from the time they are formed during DNA replication until the cell divides. 鈥淢y lab uses the fruit fly to study the molecules and mechanisms that operate during meiosis,鈥 Bickel says. 鈥淲e have recently shown that cohesion weakens when oocytes undergo aging, which leads to segregation errors. Now our goal is to understand what causes cohesion to deteriorate.鈥
Teamwork: Viji Subramanian, a former graduate student of Bickel鈥檚, laid much of the groundwork for the current study. Two graduate students, Pei Zhou and Katie Weng , and a research technician, Charlotte Jeffreys, are now moving the work forward.
, assistant professor of surgeryTriological Society 鈥淭issue Oxygenation and Optimizing Intervention in Wound Healing鈥
Healing forces: 鈥淪carring is an inevitable consequence of surgery, and all surgeons aim to minimize this complication,鈥 says Chen. In this study, electron paramagnetic resonance (EPR) oximetry offers the ability to investigate the short- and long-term role of oxygen during the process of acute and chronic injury.
Expanding research: Chen鈥檚 previous research focused on investigating hypoxia-induced signaling pathways in tumor cell lines as well as measuring tumor oxygenation. 鈥淭his project takes one step away from tumor hypoxia by investigating tissue oxygenation using a novel technique (EPR oximetry) and correlating tissue oxygenation with wound healing outcomes,鈥 reports Chen.
Teamwork: Key collaborators are Research Assistant Professor Ben Williams, associate director of the Electron Paramagnetic Resonance (EPR) Center at Dartmouth Medical School, and Lesley Jarvis, radiation oncologist at Dartmouth-Hitchcock Medical Center.
, research assistant professor of physics and astronomyScience Systems and Applications, Incorporated 鈥淣AIRAS Nowcast of Atmospheric Ionizing Radiation for Aviation Safety鈥
Harmful rays: Galactic cosmic rays (GCRs) from astrophysical sources and solar energetic particles (SEPs) produced by the sun during solar active periods are sources of ionizing radiation in the Earth鈥檚 upper atmosphere, Kress explains. GCRs and SEPs are damaging to electronic equipment in space and at high altitudes and can expose astronauts, airline crews, and passengers to increased levels of harmful radiation.
Radiation dose assessment: The goal of the NAIRAS project, Kress notes, 鈥渋s to develop a numerical forecast model of atmospheric radiation, which will provide a decision support tool for assessing radiation impacts on crew and passengers of long-range aircraft.鈥
Teamwork: Kress is collaborating on the project with Mary Hudson, professor of physics at Dartmouth. Christopher J. Mertens of NASA鈥檚 Langley Research Center and Michael Wiltberger of the National Center for Atmospheric Research are also involved.
